Secure .gov websites use HTTPS 0000002641 00000 n Fipronil, avermectin, and indoxacarb poison the ant's nervous system causing paralysis and death. Indoxacarb is considered a suitable, "low-toxicity", synthetic organophosphate replacement. Activyl features bioactivation, a mechanism of action that uses enzymes in the flea to activate the ingredients to kill the fleas. Each ml of the medication contains 195mg of indoxacarb. Be sure to follow dosage as instructed by the vet and read the label directions before use. Indoxacarb is moderately to highly toxic to fish and invertebrates. xref targets are sites in the sodium channel (indoxacarb and . However, most combinations of chlorantraniliprole and CsA showed antagonistic toxicity in third instar larvae after treatment for three days, except for 1 ng/g chlorantraniliprole and 50/ . Indoxacarb is an oxadiazine pesticide developed by DuPont that acts against lepidopteran larvae. Indoxacarb is designated by the EPA to be a "reduced-risk" pesticide and is considered an organophosphate (OP) replacement. [5] Unfortunately, equipment was not available to measure methemoglobin level in our center. 0000018372 00000 n Indoxacarb is a pyrazoline-type insecticide with low mammalian toxicity and high insecticidal activity [ 5, 6, 7 ]. Official websites use .gov Indoxacarb is the active ingredient in the new pet product, Activyl from Merck Animal Health. Once absorbed it acts on sodium channels and blocks the flow of sodium ions. An official website of the United States government. Smarter. DDT - Wikipedia DDT Dichlorodiphenyltrichloroethane, commonly known as DDT, is a colorless, tasteless, and almost odorless crystalline chemical compound, [5] an organochloride. The European Union [5] and United Kingdom [6] both banned it in 2022, on the ground, in the UK case, of "unacceptable risk to operators, workers, resident, and bystanders from the representative uses". However, symptoms of headache and lethargy, The insecticide-infused bait acts slowly, causing the worker ants to feed and carry the mixture back to the nest and its occupants, including the queen. It is fairly lipophilic with a Kow of 4.65. Indoxacarb Petition and Response. KliinllFt4@TD@ --KK +f666!RR266C]\\CC0Mg J L7FAA$(&3ATF8l>PP(B =l 6<6Y`~`ChQna`R@lv$ L1@; b*fXN;\>AY1IBr$'6$c``q!F z9vx_fT300la .pM,T@ + Find more information about exclusive use periods, Registration Information by Type of Pesticide. A-Mh6-@@/4A@kM[K,A/!hWOi?a^hWcWw74K={\V-Zc;,oY}+VxaEavUX=}OZ_u=u3xn _~kq[MoS~gu?n^ [,]{h^0 Uv|6~0!4,~ w!!wYgRz(`EY8FtZ/l&OS6he&CAlWeVFI$INW;t_a% Rh^zWCuk;G#TH*7g6pYS?DhPRB*dsp@ 8^Lhb8>|TI563\Iog\4K~9wY$ 8D6Y,$t7{gUjeRe5\9GI;-=~m]x^)LRU@.SX Some neurotoxicity was present, but often at fatal doses. Please click here to see any active alerts. It is marketed under the names Indoxacarb Technical Insecticide, Steward Insecticide and Avaunt Insecticide. This Paper. No, "Outstanding service with fast shipping and in supply products, well priced and backed up by an excellent company. Replacing lost fluids and electrolytes is the most important treatment for food poisoning. Some of our partners may process your data as a part of their legitimate business interest without asking for consent. Federal Register: July 11, 2007 (Volume 72, Number 132), Commission Directive 2006/10/EC of 27 January 2006 amending Council Directive 91/414/EEC to include forchlorfenuron and indoxacarb as active substances. 0000000876 00000 n Absorbed indoxacarb is extensively metabolized (>90%) in the liver to inactive metabolites. Always ask your veterinary doctor, or pharmacist, or contact the manufacturer. To reduce exposure after spot-on treatment wash affected animals thoroughly with abundant lukewarm water and soap to remove the chemicals from the animal's hair coat. xb```@ Y8v1smY3bW5)K!Sk+& "&5l,ce{6s2QvP,.ID$Mv-*2QZfACt77 0000002055 00000 n The normal dose is 15 mg/kg or 0.077 ml/kg of your dog's body weight [8]. This pesticide should be used with caution since some insects such as the oriental tobacco budworm (Helicoverpa assulta) become resistant when exposed.[4]. If inhaled : Take the victim into fresh air. We and our partners use cookies to Store and/or access information on a device. 2. 0000031541 00000 n Finished products contain one or more active ingredients, but also other ingredients that can be relevant from the safety point of view. Activyl is a spot-on (topical) flea treatment for dogs and cats. An example of data being processed may be a unique identifier stored in a cookie. Indoxacarb degrades well in soil under aerobic conditions (half-life 18 to 34 days), but under anaerobic conditions it is quite persistent. Indoxacarb is a white powdered solid material formulated as a wettable granule and soluble concentrate. The results indicated that indoxacarb was highly effective against second instar larvae of S. littoralis where the LC50 was 0.041 mg/l. Previous reports have suggested the occurrence of methemoglobinemia after indoxacarb ingestion, but no case of indoxacarb-induced systemic toxicity, such as acute renal failure, has been reported thus far. Indoxacarb is a pesticide that is used to kill lepidopteran larvae such as butterflies and moths. Indoxacarb is considered a suitable, "low-toxicity", synthetic organophosphate replacement. If breathing is irregular or stopped, administer artificial respiration. To reduce exposure after spot-on treatment wash affected animals thoroughly with abundant lukewarm water and soap to remove the chemicals from the animal's hair coat. It breaks down quickly when exposed to sunlight. DDT was first synthesized in 1874 by the Austrian chemist Othmar Zeidler. PubChem . [ 1] But NEVER use mosquito repellents containing DEET on your pets or you could cause a fatal poisoning. Yes| United States Environmental Protection Agency. 0000001950 00000 n MSDSs target safety during manufacturing, transport, storage and handling of such materials. Guideline No./ Study Type MRID No. [12] Methemoglobinemia is a condition which ultimately decreases the effectiveness of red blood cells to exchange oxygen with organs. A .gov website belongs to an official government organization in the United States. 0000029642 00000 n indoxacarb is the iso approved name for a new oxadiazine insecticide, methyl ( s )- n - [7-chloro-2,3,4a,5-tetrahydro-4a- (methoxycarbonyl)indeno [1,2- e ] [1,3,4]oxadiazin-2-ylcarbonyl]-4'- (trifluoromethoxy)carbanilate (iupac), also known as methyl (4a s )-7-chloro-2,5-dihydro-2- [ [ (methoxycarbonyl) [4- Ingestion of indoxacarb may produce not only methemoglobinemia, but also systemic toxicities like acute renal failure, which can be successfully treated with aggressive therapy such as continuous veno-venous hemofiltration. 0000030063 00000 n Acute Toxicity Data on STEWARD TM Insecticide (EPA File Symbol 352-598) (14.7% indoxacarb, 4.3% R-enantiomer). National Center for Biotechnology Information. Lakshmi Prasanna. It has low acute toxicity and is not well absorbed through the skin, but with longer-term exposure, it is toxic to the liver and is a Probable carcinogen. Discussion: Ingestion of indoxacarb may produce not only methemoglobinemia, but also systemic toxicities like acute renal failure, which can be successfully treated with aggressive therapy such as continuous veno-venous hemofiltration. It blocks the movements of sodium ions in certain nerve cells, which results in paralysis and death of the affected insects. In sub-chronic toxicity studies (90 days) on, Usual therapeutic dose of indoxacarb (after topical administration as a. V%jo_\(5J*+c1>@~4D>{O*!216v 0000002491 00000 n Methemoglobinemia can be fatal if left untreated, but proper treatment of this condition can rapidly begin reversing it. It is an oxadiazine based pesticide established by Dupont and marketed under various brand names such as Avaunt Insecticide, Steward Insecticide and Indoxacarb Technical Insecticide. Excretion is mainly through the feces. Hl[pu%!SB$!6L!P-dYV{vWH+j]YW[%`pK0`hZL;6M2m33e$G23}|gs~o6CMMM^{cK^yrv`Y~t;N_?_uVVkak55^jv7Co@>z: indoxacarb: Reproductive toxicity - Assessment: No toxicity to reproduction. Was this article informative and helpful to you? [7][8], Indoxacarb is the active ingredient in a number of household insecticides, including cockroach and ant baits, and can remain active after digestion. Petition (s) and Response (s) for Indoxacarb. United States Environmental Protection Agency. 0000034342 00000 n Indoxacarb has only moderate to low toxicity, meaning that it does not cause carcinogenic, mutagenic, or developmental effects in people or pets when used in residential and commercial areas. One report from Korea shows methemoglobinemia and acute renal failure following indoxacarb poisoning, which was treated successfully with hemodialysis. Percentage mortality was calculated after 72 h of treatment. Dogs, cats, ferrets, house rabbits, and pet pigs may also be attracted to the baits. Fortunately, many of these insecticides don't work exactly the same way in humans or are in such low concentrations in the baits as to have low risk for unintentional poisoning. Pest control products containing Indoxacarb as an active ingredient are typically used on a wide range of crops for ants, roaches, and other sucking pests. Discussion. It has moderate to low acute and chronic toxicity and does not cause mutagenic, carcinogenic, developmental, or reproductive effects. To view the purposes they believe they have legitimate interest for, or to object to this data processing use the vendor list link below. Contact with the substance can take place through ingestion, physical contact, translaminar action, during preening, and at rewetting of surfaces. Treatment consists in preventing further exposure together with supportive and symptomatic measures. Indoxacarb is a broad-spectrum non-organophosphorus oxidiazine insecticide widely used in farming. tjl6y|.aig~8RiY{]]-v~a s';|^sDOddK`-QylwPqL,]i)s[\y{&sB}*g-p$ vW tX+@f/`yb2Ug(SforvG:| U6YP$Oa&@y@e>k%Pc^S:Ul2IL@_mq`syL-G +4M07y>(Yz6/&Kgq(c(|& @z+a'F^?;C} This chemical is produced by DuPont and marketed in the U.S. as StewardTM, AvauntTM, and Technical IndoxacarbTM. Sitio en ingls - Privadidad y cookies - Mapa del sitio - Contacto - Sobre este sitio. , treatment with specific antidote, methylene blue, or Vitamin C, and hyperbaric oxygen should be considered. Our patient had consumed indoxacarb . Ant trap Indoxacarb usually contains substances that are attracted to ants. 0000029255 00000 n ;u }?tHXNY(R vRWLgs$0~w0|h(!Y>$+(hG?/8C+"~u.z|kX!_7r]hQXe)%\ n$vf9[C:}7/|Nv9V@_"\XAT$ZKhwSAZSQ@eG^o9f.LUx?a0#!(r. 0000018931 00000 n ", 2004-2022 P&M Solutions, LLC DBA DoMyOwn, Customize Your Own DIY Pest Control Program. There is no antidote for indoxacarb poisoning. 0000012642 00000 n [1,4] Methemoglobinemia has been reported in a few cases of indoxacarb poisoning. The toxicity of an active ingredient must not be confused with the toxicity of finished products, in this case parasiticidal drugs or pesticides. If you would like to change your settings or withdraw consent at any time, the link to do so is in our privacy policy accessible from our home page. While toxicity to humans has not been formally studied, there has been a report of a person trying to consume indoxacarb in a suicide attempt. Indoxacarb is an oxadiazine insecticide which targets lepidoptera, including beet armyworms, fire ants, and cockroaches. Sign in for a personalized shopping experience and faster checkout. Continue with Recommended Cookies, WHO Acute Hazard classification of pesticides: II, moderately hazardous. The worker ant signals the other worker ants to go eat the delicious bait, and then takes it home. Treatment consists in preventing further exposure together with. Nevertheless, no this regarding guarantee is given, and any liability on its accuracy, integrity, sufficiency, actuality and opportunity is denied. GENERAL INFORMATION UK regulatory status 0000013236 00000 n It is considered as a "reduced-risk" pesticide which replaces organophosphate pesticides. Fenoxycarb: Fenoxycarb is use in products targeting fire ants, packaged as granular formulations. Updated 20 January 2007. https://en.wikipedia.org/w/index.php?title=Indoxacarb&oldid=1111978412, 88.1C (190.6F; 361.2K) 99% indoxacarb PAI, This page was last edited on 24 September 2022, at 01:08. [10] Petition for Indoxacarb (pdf) (1.26 MB) EPA Response to Petition for Indoxacarb (pdf) (2.51 MB) Last updated on October 4, 2022. SAFETY DATA SHEET ADVION MICROFLOW INSECT BAIT Version 1.0 Revision Date: 10/05/2021 SDS Number: You need to get the right size applicator according to how big your dog is. Indoxacarb begins working when target pests either come into contact with the chemical or ingest treated foliage and fruit. Fortunately few deaths occur from this product, presumably as most dogs and cats don't come in contact with enough to kill them. Indoxacarb | C22H17ClF3N3O7 | CID 107720 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. 0000000016 00000 n Indoxacarb (Avaunt WG, DuPont Corp.) ranked highest overall for safety to beneficial insects, largely because of its low dermal toxicity to all species tested. 0000012261 00000 n We report a case of systemic toxicity induced by indoxacarb, an oxadiazine insecticide. Indoxacarb is an oxadiazine pesticide used for control of cotton bollworm and native budworm in cotton and soyabeans. A lock (LockA locked padlock) or https:// means youve safely connected to the .gov website. Office of Prevention, Pesticides and Toxic Substances (7505C). Official Journal of the European Union 2006-1-28, https://www.lab-sl.com/en/eu-bans-the-use-of-the-active-substance-indoxacarb-normally-used-as-a-pesticide-insecticide/, "HSE to withdraw authorisation for use of indoxacarb pesticide", 10.1002/1526-4998(200102)57:2<153::aid-ps288>3.0.co;2-o, "Indoxacarb Insecticide Wipes Out Entire Cockroach Generations", "Indoxacarb poisoning: An unusual presentation as methemoglobinemia", "Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels", Moncada, Adriana. 0000012933 00000 n Adults. . Todos los derechos reservados. 1-3 Bait traps have very low concentrations of insecticides and have a wide margin of safety in dog and cat exposures. of this mechanism, indoxacarb is considered a voltage-dependent sodium channel blocker.4 Insects are exposed via inges on of treated foliage/fruit and direct physical contact. 0 Environmental Monitoring Branch, Department of Pesticide Regulation, State of California. Petition(s) and Response(s) forIndoxacarb. Indoxacarb is a broad-spectrum non-organophosphorus oxidiazine insecticide widely used in farming. center or physician, or going for treatment. startxref P. Junquera 2007-2022. FACT SHEET (New Chemical) Indoxacarb Page 6 of 17 Table 4. Acute Toxicity Acute toxicity studies suggest that indoxacarb can cause skin sensi za- on. 189 0 obj<>stream 187 0 obj<> endobj There is no antidote for DEET poisoning and all animals are treated symptomatically. Share sensitive information only on official, secure websites. Poisoning, intoxication, overdose, antidote, Acute Toxicity and Tolerance of Indoxacarb, Toxic Symptoms caused by Indoxacarb Poisoning, Indoxacarb Side Effects, Adverse Drug Reactions (ADRs) and Warnings, Antidote and Treatment of Indoxacarb Intoxication, WHO Acute Hazard classification of pesticides, Abamectina para perros, gatos, bovinos y otro ganado, Amitraz para perros, bovinos, ovinos y porcinos, Cihalotrina para bovinos, ovinos y otro ganado, Cipermetrina para perros, bovinos, ovinos y otro ganado, Doramectina para bovinos, ovinos y porcinos, Flubendazol para mascotas, porcinos y aves, Mebendazol para porcinos, aves y mascotas, Moxidectina para bovinos, ovinos y perros, Niclosamida para bovinos, ovinos y mascotas, Permetrina para perros, bovinos y otro ganado, Ricobendazol para bovinos, ovinos y mascotas, Spinosad para perros, gatos, ovinos y aves, Triclorfon (=metrifonato) para ganado y mascotas. If you intend to use a veterinary drug containing this active ingredient you must carefully read and follow the safety instructions in the product label. [12] The patient developed methemoglobinemia following ingestion. Date Issued: October 30, 2000. JavaScript appears to be disabled on this computer. INDOXACARB: SAFETY SUMMARY for VETERINARY use in DOGS and CATS. %%EOF This safety summary is a complement to the information on product labels and MSDS. Environmental Fate of Indoxacarb. Hydramethylnon interferes with a cell's ability to produce energy. The information in this page must not be confused with theMaterials and Safety Datasheets (MSDS) officially issued by manufacturers for active ingredients and many other chemicals. How to apply Activyl on dogs 0000003092 00000 n Starting at $9.98/month* + Free Shipping . Bangalore treated a case of indoxacarb poisoning with methylene blue 2 mg/kg in 100 ml normal saline and ascorbic acid 500 mg in 5% dextrose which were continued for two days along with non-invasive ventilation.4 Chhabra et al from Delhi treated a patient with indoxacarb poisoning TIu![u Gq:=^{CT1#d'|N8#M@Ci/81 ` [ 0000002183 00000 n It contains similar features as Advion Cockroach Gel Bait, including the active ingredient indoxacarb with a non-staining, odorless formulation.Pest management professionals can receive yearlong rebates on purchases of Advion Evolution Cockroach Gel Bait with the PestPartners 365 Program. 0000035219 00000 n subsites, receptor subunit interfaces, or transmembrane regions. 0000018755 00000 n trailer Indoxacarb is an antiparasitic agent primarily used to kill adult fleas. Indoxacarb is a common ingredient in ant traps as well as various topical medications that are formulated to get rid of ticks or fleas. Reason for Issuance: Conditional Registration. Insects use an esterase/amidase to decarbomethoxylate indoxacarb to N-decarbomethoxyllate JW062 (DCJW). The consent submitted will only be used for data processing originating from this website. endstream endobj 188 0 obj<> endobj 190 0 obj<>/Font<>>>/DA(/Helv 0 Tf 0 g )>> endobj 191 0 obj<>/ProcSet[/PDF/Text]/ExtGState 192 0 R>>/LastModified(D:20070227092314+05'30')>> endobj 192 0 obj<> endobj 193 0 obj<> endobj 194 0 obj/Default endobj 195 0 obj<> endobj 196 0 obj<>stream To reduce exposure after spot-on treatment wash affected animals thoroughly with abundant lukewarm water and soap to remove the chemicals from the animal's hair coat. Aerosol Sprays and Foggers Find more information about exclusive use periods. Advion Roach & Ant Products: "Faster. This insecticide shows excellent field activity against the lepidopteran and coleopteran pests of cotton, corn, peanuts, soybeans, vegetables, fruits, and other crops [ 8 ]. A small amount is also ingested through licking and/or grooming (particularly in cats). L -1 treatment at 7 C was underestimated and overestimated . 95 of 101 people found this article informative and helpful. [1] [2] [3] 0000019475 00000 n We report a case of indoxacarb poisoning in a farmer following suicidal consumption, manifested as unconsciousness, cyanosis Indoxacarb has been classified as a "reduced risk" pesticide by the EPA. Sixteen cats were selected for the study and allocated to two treatment groups. In toxicity studies in rats, rabbits and dogs the following toxic symptoms were observed after heavy oral overdosing: weakness, depression, salivation (drooling), abnormal gait or movements, inability to stand, head tilting.